{"id":19376052,"date":"2024-09-16T16:23:00","date_gmt":"2024-09-16T20:23:00","guid":{"rendered":"https:\/\/allergyasthmanetwork.org\/?page_id=19376052"},"modified":"2025-05-16T10:54:11","modified_gmt":"2025-05-16T14:54:11","slug":"mast-cell-diseases","status":"publish","type":"page","link":"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/","title":{"rendered":"What Are Mast Cell Diseases?"},"content":{"rendered":"<style>.kadence-column19383844_5879ee-1b5 > .kt-inside-inner-col,.kadence-column19383844_5879ee-1b5 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19383844_5879ee-1b5 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19383844_5879ee-1b5 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19383844_5879ee-1b5 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19383844_5879ee-1b5 > 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#f2f2f2;}.kt-accordion-id19383844_7e85f8-aa3 .kt-accordion-header-wrap .kt-blocks-accordion-header:hover, body:not(.hide-focus-outline) .kt-accordion-id19383844_7e85f8-aa3 .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible{border-top-color:#eeeeee;border-top-style:solid;border-right-color:#eeeeee;border-right-style:solid;border-bottom-color:#eeeeee;border-bottom-style:solid;border-left-color:#eeeeee;border-left-style:solid;}.kt-accordion-id19383844_7e85f8-aa3 .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible, .kt-accordion-id19383844_7e85f8-aa3 .kt-accordion-header-wrap .kt-blocks-accordion-header.kt-accordion-panel-active{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}<\/style>\n<div class=\"wp-block-kadence-accordion alignnone\"><div class=\"kt-accordion-wrap kt-accordion-id19383844_7e85f8-aa3 kt-accordion-has-3-panes kt-active-pane-0 kt-accordion-block kt-pane-header-alignment-left kt-accodion-icon-style-basic kt-accodion-icon-side-right\" style=\"max-width:400px\"><div class=\"kt-accordion-inner-wrap\" data-allow-multiple-open=\"false\" data-start-open=\"none\">\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-1 kt-pane19383844_6b51b2-8c2\"><div class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">See Other Mast Cell Diseases Pages<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/div><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\"><style>.wp-block-kadence-navigation19383842-cpt-id{--kb-nav-dropdown-border-top-left-radius:0px;--kb-nav-dropdown-border-top-right-radius:0px;--kb-nav-dropdown-border-bottom-right-radius:0px;--kb-nav-dropdown-border-bottom-left-radius:0px;--kb-nav-dropdown-border-radius-top:0px;--kb-nav-dropdown-border-radius-right:0px;--kb-nav-dropdown-border-radius-bottom:0px;--kb-nav-dropdown-border-radius-left:0px;--kb-nav-dropdown-toggle-border-left:1px solid var(--global-palette9, #ffffff);--kb-nav-top-not-last-link-border-bottom:1px solid var(--global-palette9, #ffffff);--kb-nav-top-not-last-link-border-right:var(--kb-nav-link-border-right);}.header-desktop-transparent .wp-block-kadence-navigation19383842-cpt-id{--kb-nav-top-not-last-link-border-right:var(--kb-nav-link-border-right);}.item-is-stuck 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767px){.wp-block-kadence-navigation19383842-cpt-id{--kb-nav-dropdown-toggle-border-left:var(--kb-nav-link-border-left);--kb-nav-top-not-last-link-border-bottom:var(--kb-nav-link-border-bottom);}.header-mobile-transparent .wp-block-kadence-navigation19383842-cpt-id{--kb-nav-dropdown-toggle-border-left:var(--kb-nav-link-border-left);--kb-nav-top-not-last-link-border-bottom:var(--kb-nav-link-border-bottom);}.item-is-stuck .wp-block-kadence-navigation19383842-cpt-id{--kb-nav-dropdown-toggle-border-left:var(--kb-nav-link-border-left);--kb-nav-top-not-last-link-border-bottom:var(--kb-nav-link-border-bottom);}}<\/style><div class=\"wp-block-kadence-navigation19383842-cpt-id kb-nav-desktop-horizontal-layout-standard kb-nav-tablet-horizontal-layout-standard kb-nav-mobile-horizontal-layout-standard navigation-desktop-layout-fill-stretch-false navigation-tablet-layout-fill-stretch-false navigation-mobile-layout-fill-stretch-false navigation-desktop-orientation-vertical navigation-tablet-orientation-vertical navigation-mobile-orientation-vertical wp-block-kadence-navigation\" data-scroll-spy=\"\"><nav class=\"navigation navigation-desktop-style-standard navigation-tablet-style-standard navigation-mobile-style-standard navigation-desktop-dropdown-animation-none navigation-tablet-dropdown-animation-none navigation-mobile-dropdown-animation-none navigation-desktop-collapse-sub-menus-true navigation-tablet-collapse-sub-menus-true navigation-mobile-collapse-sub-menus-true navigation-desktop-parent-toggles-menus-false navigation-tablet-parent-toggles-menus-false navigation-mobile-parent-toggles-menus-false navigation-desktop-parent-active-false navigation-tablet-parent-active-false navigation-mobile-parent-active-false\"><div class=\"menu-container\"><ul class=\"kb-navigation menu collapse-sub-nav-desktop-true collapse-sub-nav-tablet-true collapse-sub-nav-mobile-true\">\n<style>.kb-nav-link-19383842_ba9eed-601 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_ba9eed-601 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_ba9eed-601 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/\">What Are Mast Cell Diseases?<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_f0e061-fb2 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_f0e061-fb2 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_f0e061-fb2 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mastocytosis\/\">What is Mastocytosis?<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_a4b5f4-cf3 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_a4b5f4-cf3 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_a4b5f4-cf3 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mcas\/\">Mast Cell Activation Syndrome (MCAS)<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_23a687-2a4 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_23a687-2a4 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_23a687-2a4 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/hat\/\">What is Hereditary Alpha Tryptasemia?<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_988eb2-6f5 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_988eb2-6f5 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_988eb2-6f5 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mcd-in-skin-of-color\/\">Mast Cell Disease in Skin of Color<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_b73b4b-366 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_b73b4b-366 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_b73b4b-366 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/living-with-mcd\/\">Living with Mast Cell Disease<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_51416c-fc7 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_51416c-fc7 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_51416c-fc7 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mental-health-for-mcd\/\">Mental Health and Mast Cell Disorders<\/a><\/div><\/li>\n\n<style>.kb-nav-link-19383842_d5195d-93 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-highlight-order:3;--kb-nav-link-media-container-order:3;}.kb-nav-link-19383842_d5195d-93 > .kb-link-wrap.kb-link-wrap.kb-link-wrap.kb-link-wrap{--kb-nav-link-media-max-width:px;}<\/style><li class=\"kb-nav-link-19383842_d5195d-93 menu-item wp-block-kadence-navigation-link\"><div class=\"kb-link-wrap\"><a class=\"kb-nav-link-content\" href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mcd-glossary\/\">MCD Glossary of Terms<\/a><\/div><\/li>\n<\/ul><\/div><\/nav><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_8fa858-44 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_8fa858-44 > .kt-inside-inner-col,.kadence-column19376052_8fa858-44 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_8fa858-44 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_8fa858-44 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_8fa858-44 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_8fa858-44 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_8fa858-44{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_8fa858-44 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_8fa858-44 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_8fa858-44\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_40be0f-3b{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_40be0f-3b{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col,.kadence-column19376052_40be0f-3b > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_40be0f-3b{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_40be0f-3b{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_40be0f-3b > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_40be0f-3b{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_40be0f-3b > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_40be0f-3b\"><div class=\"kt-inside-inner-col\"><style>.kb-image19376052_3c9ef2-72 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_3c9ef2-72 size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/woman-with-abdominal-pain-1080x567.jpg\" alt=\"a woman with abdominal pain holds her stomach\" class=\"kb-img wp-image-1278\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/woman-with-abdominal-pain-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/woman-with-abdominal-pain-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/woman-with-abdominal-pain-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/woman-with-abdominal-pain.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<p>Mast cells play an important role in our health. These tissue-based immune cells live in every organ in our body. Mast cells act as sentinels for the immune system. They are armed to recognize and respond to foreign invaders, such as a virus or an allergen. The sentinels counterattack with powerful chemical mediators that seek to repair tissue after the harm is contained.<\/p>\n\n\n\n<p>When these mast cells start to increase in number or release chemical mediators at the wrong time, it can result in mast cell disease.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"\ud83c\udf1f Understanding Mast Cell Diseases: Symptoms, Diagnosis, and Treatment \ud83c\udf1f\" width=\"720\" height=\"405\" src=\"https:\/\/www.youtube.com\/embed\/Ppa2jfjOpDw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Mast cell diseases are caused by abnormal and\/or overly active mast cells. Some people are born with a mast cell disease. Others may get it in childhood or adulthood. Mast cell diseases are rare, but they are increasingly recognized and diagnosed by doctors. The most common are mastocytosis, mast cell activation syndrome (MCAS) and hereditary alpha-tryptasemia syndrome (H\u03b1T).<\/p>\n\n\n\n<p>Common symptoms of mast cell diseases include skin rashes, unexplained flushing, stomach pain, gastrointestinal tract problems, nausea, bloating and bone or joint pain. People with mast cell diseases might suddenly feel hot, even in a normal-temperature room. They may have a severe reaction to certain foods, medicines or an insect sting. They may struggle with life-threatening symptoms.<\/p>\n\n\n\n<p>Symptoms might suggest an allergic reaction. But what to do if allergy testing is inconclusive? In this case, your doctor may evaluate you for a mast cell disease.<\/p>\n\n\n<style>.kb-image19376052_9f6606-14.kb-image-is-ratio-size, .kb-image19376052_9f6606-14 .kb-image-is-ratio-size{max-width:600px;width:100%;}.wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_9f6606-14.kb-image-is-ratio-size, .wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_9f6606-14 .kb-image-is-ratio-size{align-self:unset;}.kb-image19376052_9f6606-14 figure{max-width:600px;}.kb-image19376052_9f6606-14 .image-is-svg, .kb-image19376052_9f6606-14 .image-is-svg img{width:100%;}.kb-image19376052_9f6606-14 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image19376052_9f6606-14\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"800\" height=\"768\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/What-are-mast-cell-diseases.jpg\" alt=\"Infographic titled &quot;What Are Mast Cell Diseases?&quot; It details common symptoms affecting multiple organ systems, including the brain, heart, stomach, bones, and skin, with an emphasis on risks of severe allergic reactions.\" class=\"kb-img wp-image-19379183\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/What-are-mast-cell-diseases.jpg 800w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/What-are-mast-cell-diseases-300x288.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/What-are-mast-cell-diseases-768x737.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">What are mast cells?<\/h2>\n\n\n\n<p>Mast cells are white blood cells in our immune system. They reside in body tissue and help protect us from viruses, germs, allergens, irritants and toxins. When mast cells detect one of these invaders, they help fight it off by releasing chemical mediators. But in the process of doing so, they trigger inflammation that can lead to symptoms in multiple body organs.<\/p>\n\n\n\n<p>In people with mast cell diseases, the mast cells don\u2019t work right. They may multiply too fast or over-react, sometimes in response to certain triggers such as allergens. When this happens, it can disrupt the function of the body organs. Mast cells are responsible for allergic reactions, including anaphylaxis (a severe allergic reaction).<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col,.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{background-color:#f8f7f3;}.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_b0b67b-40{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_b0b67b-40 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_b0b67b-40\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_14a727-58{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_14a727-58{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_14a727-58 > .kt-inside-inner-col,.kadence-column19376052_14a727-58 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_14a727-58 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_14a727-58 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_14a727-58 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_14a727-58 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_14a727-58{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_14a727-58{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_14a727-58 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_14a727-58{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_14a727-58 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_14a727-58\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"What are the signs I have a mast cell disease instead of a severe allergy? with Leena Padhye, MD\" width=\"720\" height=\"405\" src=\"https:\/\/www.youtube.com\/embed\/YvosZAGEVXE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What are the symptoms of mast cell disease?<\/h2>\n\n\n\n<p>Some people with mast cell diseases may have occasional symptoms. Others may have daily symptoms. Everyone\u2019s symptoms are different but may involve multiple organ systems, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin: a rash, skin lesions, flushing, swelling<\/li>\n\n\n\n<li>Stomach: Abdominal pain, nausea, vomiting, diarrhea, heartburn<\/li>\n\n\n\n<li>Brain: Feeling confused, trouble thinking, feeling anxious or sad, shaking, headaches<\/li>\n\n\n\n<li>Bones: Weak bones, bone pain<\/li>\n\n\n\n<li>Heart: Blood pressure changes, heart racing, fainting<\/li>\n\n\n\n<li>Breathing: Shortness of breath<\/li>\n\n\n\n<li>Anaphylaxis (a life-threatening allergic reaction)<\/li>\n<\/ul>\n\n\n\n<p>Symptom triggers can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Heat, cold or temperature change<\/li>\n\n\n\n<li>Friction or vibration on the skin<\/li>\n\n\n\n<li>Stress<\/li>\n\n\n\n<li>Pain<\/li>\n\n\n\n<li>Exercise<\/li>\n\n\n\n<li>Bug bites or stings<\/li>\n\n\n\n<li>Alcohol<\/li>\n\n\n\n<li>Contrast dyes that you might receive during a medical test<\/li>\n\n\n\n<li>Certain foods or medicines<\/li>\n\n\n\n<li>Infections<\/li>\n<\/ul>\n\n\n\n<p>Patients may have many symptoms and triggers. They may visit many doctors seeking treatment. It can be difficult for some to find a doctor who connects the dots to a mast cell disease.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col,.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_d6646f-e8{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_d6646f-e8 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_d6646f-e8\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_84d55e-99{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_84d55e-99{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col,.kadence-column19376052_84d55e-99 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_84d55e-99{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_84d55e-99{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_84d55e-99 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_84d55e-99{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_84d55e-99 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_84d55e-99\"><div class=\"kt-inside-inner-col\"><style>.kb-image19376052_894403-df .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_894403-df size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-patient-for-MCD-symptoms-1080x567.jpg\" alt=\"A doctor in a white coat uses a stethoscope to listen to the heartbeat of a patient sitting on an examination table. They are smiling at each other. A medical poster of the human heart is visible on the wall in the background.\" class=\"kb-img wp-image-19379218\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-patient-for-MCD-symptoms-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-patient-for-MCD-symptoms-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-patient-for-MCD-symptoms-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-patient-for-MCD-symptoms.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How are mast cell diseases diagnosed?<\/h2>\n\n\n\n<p>If you think you may have a mast cell disease, consider seeing a specialist. A board-certified allergist and immunologist can help with the diagnosis. Other specialists that can help with diagnosis include a gastroenterologist, dermatologist, endocrinologist and hematologist.<\/p>\n\n\n\n<p>Mast cell disease signs and symptoms may vary in different people since mast cells can cause problems in any part of the body. Doctors will examine the skin for lesions. If lesions are found, the doctor will stroke the lesion to see if hives develop. This is called Darier\u2019s sign and it usually indicates a mast cell disease is present. (If there are no lesions but stroking the skin still causes hives, then the diagnosis may be non-clonal or secondary mast cell disease.)<\/p>\n\n\n\n<p>Blood and urine tests are common diagnostic tools. In a blood test, doctors look for serum tryptase \u2013 a marker of mast cell burden or activation \u2013 both at the baseline level and during a mast cell reaction. Urine tests examine for rises in histamine, leukotriene C4 or prostaglandin D.<\/p>\n\n\n\n<p>Doctors may conduct a biopsy. In a biopsy, the doctor removes a small part of the skin or bone marrow and look at it under a microscope. This can confirm a mast cell disease diagnosis.<\/p>\n\n\n\n<p>Doctors might order CT scans to see how your mast cells are affecting your body. Some patients may undergo genetic tests as well to confirm a diagnosis.<\/p>\n\n\n<style>.kb-image19376052_8f4f5b-bb .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_8f4f5b-bb size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-woman-with-mcd-symptoms-1080x567.jpg\" alt=\"A doctor wearing a white coat and glasses uses a stethoscope to listen to the heartbeat of a smiling woman sitting in an examination room. The woman is wearing a light blue shirt.\" class=\"kb-img wp-image-19379215\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-woman-with-mcd-symptoms-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-woman-with-mcd-symptoms-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-woman-with-mcd-symptoms-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-checking-woman-with-mcd-symptoms.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Diagnosing Mast Cell Disease in Skin of Color<\/h3>\n\n\n\n<p>Diagnostic criteria may differ between people with light skin and darker skin. Mast cell disease often involves skin symptoms: spots or rashes. For people with light skin, there is redness on the skin. For people of color, the affected skin may appear purple, brown, tan or gray. Reddish-brown spots, called urticaria pigmentosa, may be less noticeable on darker skin. Rashes may be less noticeable or visible on darker skin than in people with lighter skin.<\/p>\n\n\n\n<p>Misdiagnosis and delayed diagnosis of mast cell disease are common in people of color. Medical training has improved in recent years. But more research on mast cell disease in people of color is needed.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_deba71-f2 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_deba71-f2 > .kt-inside-inner-col,.kadence-column19376052_deba71-f2 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_deba71-f2 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_deba71-f2 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_deba71-f2 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_deba71-f2 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_deba71-f2{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_deba71-f2 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_deba71-f2 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_deba71-f2\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_f615a2-15{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_f615a2-15{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col,.kadence-column19376052_f615a2-15 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_f615a2-15{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_f615a2-15{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_f615a2-15 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_f615a2-15{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_f615a2-15 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_f615a2-15\"><div class=\"kt-inside-inner-col\"><style>.kb-image19376052_ce0a44-36 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_ce0a44-36 size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-working-wtih-patient-1080x567.jpg\" alt=\"A doctor in a white coat and glasses smiles while showing a medication bottle to a patient with long blonde hair. The patient wears a blue and white striped shirt. Both are seated at a table in a bright office.\" class=\"kb-img wp-image-19379211\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-working-wtih-patient-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-working-wtih-patient-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-working-wtih-patient-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Doctor-working-wtih-patient.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How are mast cell diseases treated?<\/h2>\n\n\n\n<p>Mast cell disease treatment first involves addressing severe symptoms from anaphylaxis. Managing mast cell disease may include using medications that reduce the mast cell action.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Anaphylaxis treatment<\/h3>\n\n\n\n<p>Some people with mast cell disease may experience anaphylaxis, a severe reaction. It results from a sudden, rapid release of the mediators from mast cells. <a href=\"https:\/\/allergyasthmanetwork.org\/anaphylaxis\/what-is-epinephrine\/\"><strong><u>Epinephrine<\/u><\/strong><\/a> is the first line of treatment for anaphylaxis. Give epinephrine at the first sign of severe symptoms. It is the only medication that can reverse anaphylaxis. Epinephrine can cause side effects such as anxiety, dizziness, shakiness, headache, and nausea, but these are usually mild and not life-threatening.<\/p>\n\n\n\n<p>Keep epinephrine with you at all times. Carry two devices of epinephrine in case symptoms return after the first dose.<\/p>\n\n\n\n<p>If your symptoms improve after one dose of epinephrine and you\u2019re feeling better, you do not need to go the hospital or emergency department. However, you should administer a second dose and seek emergency medical help if\u2026<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>symptoms return or worsen after the first dose of epinephrine;<\/li>\n\n\n\n<li>you have severe anaphylaxis;<\/li>\n\n\n\n<li>symptoms do not go away promptly or completely after the first dose of epinephrine.<\/li>\n<\/ul>\n\n\n\n<p>If you do not have epinephrine readily available, call 911, or go to the hospital, emergency department or urgent care clinic right away for treatment. Do not delay!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Medications<\/h3>\n\n\n\n<p>Medications are available to make mast cells less reactive. They also block the effects of mast cell mediators. These medications include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>H1 and H2 antihistamines \u2013 blocks the effects of histamine and reduce symptoms<\/li>\n\n\n\n<li>Mast cell stabilizers (cromolyn sodium, ketotifen) &#8211; prevents mast cells from releasing histamine and leukotrienes<\/li>\n\n\n\n<li>Leukotriene inhibitors such as montelukast &#8211; blocks leukotrienes, inflammatory chemicals released by mast cells<\/li>\n\n\n\n<li>Aspirin (only under direct physician\u2019s supervision)<\/li>\n\n\n\n<li>Omalizumab (brand name Xolair\u00ae) \u2013 targets the protein antibody Immunoglobulin E (IgE) to limit the release of histamine from mast cells<\/li>\n\n\n\n<li>Tyrosine kinase inhibitors for systemic mastocytosis<\/li>\n<\/ul>\n\n\n\n<p>Tyrosine kinase inhibitors are medications that can help stop symptoms before they start. They work by inhibiting the proteins that lead to a buildup of mast cells. They can also stop or limit histamine release. Three tyrosine kinase inhibitors are available to treat mastocytosis. They are avapritinib (brand name Ayvakit\u00ae), imatinib (brand name Gleevec\u00ae) and midostaurin (brand names Rydapt\u00ae and Tauritmo\u00ae). Tyrosine kinase inhibitors are taken orally as a pill. They are typically prescribed for people with advanced disease.<\/p>\n\n\n\n<p>Severe mast cell diseases may require treatment with chemotherapy. This does not mean the patient has cancer. However, people with mast cell diseases are at increased risk for certain cancers.<\/p>\n\n\n\n<p>Talk with your doctor about what medication or treatment is right for you.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col,.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_ba7d26-66{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_ba7d26-66 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_ba7d26-66\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_75daf7-9f{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_75daf7-9f{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col,.kadence-column19376052_75daf7-9f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_75daf7-9f{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_75daf7-9f{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_75daf7-9f > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_75daf7-9f{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_75daf7-9f > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_75daf7-9f\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">What are different types of mast cell disorders?<\/h2>\n\n\n\n<p>There are three main types of mast cell disease. These include mastocytosis, mast cell activation syndrome and hereditary alpha tryptasemia syndrome.<\/p>\n\n\n<style>.kb-image19376052_54758c-7d.kb-image-is-ratio-size, .kb-image19376052_54758c-7d .kb-image-is-ratio-size{max-width:600px;width:100%;}.wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_54758c-7d.kb-image-is-ratio-size, .wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_54758c-7d .kb-image-is-ratio-size{align-self:unset;}.kb-image19376052_54758c-7d figure{max-width:600px;}.kb-image19376052_54758c-7d .image-is-svg, .kb-image19376052_54758c-7d .image-is-svg img{width:100%;}.kb-image19376052_54758c-7d .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image19376052_54758c-7d\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"800\" height=\"637\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Common-Mast-cell-diseases.jpg\" alt=\"An infographic titled &quot;What are the Most Common Mast Cell Diseases.&quot; It describes three conditions: Mastocytosis, Mast Cell Activation Syndrome, and Hereditary Alpha-Tryptasemia, with details on symptoms and effects for each.\" class=\"kb-img wp-image-19379184\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Common-Mast-cell-diseases.jpg 800w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Common-Mast-cell-diseases-300x239.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Common-Mast-cell-diseases-768x612.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Mastocytosis<\/h3>\n\n\n\n<p><a href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mastocytosis\/\">Mastocytosis<\/a> is a disorder in which abnormal mast cells build up in the body. These mast cells develop a mutation that allows them to evade mechanisms that control their growth. This unchecked growth disrupts the tissue it\u2019s designed to protect. They transfer into organs including the skin, bone marrow, digestive system and respiratory system. Symptoms can include flushing, skin rashes, stomach pain, diarrhea, hypertension or hypotension, syncope and musculoskeletal pain.<\/p>\n\n\n\n<p>People with systemic mastocytosis are at higher risk for developing anaphylaxis. Severe cases are rare, but they can lead to organ failure or certain types of cancer.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mast cell activation syndrome (MCAS)<\/h3>\n\n\n\n<p>People with <a href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/mcas\/\">mast cell activation syndrome<\/a> have overactive mast cells. The mast cells release chemical mediators such as histamine too frequently. It can occur with or without exposure to an allergen trigger. People with MCAS are at higher risk for anaphylaxis. It can lead to symptoms such as hives, swelling, difficulty breathing, low blood pressure and severe diarrhea. People with MCAS also are at risk for severe allergic reactions, or anaphylaxis.<\/p>\n\n\n\n<p>Sometimes the cause of symptoms is unknown \u2013 this is called idiopathic MCAS.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Hereditary alpha-tryptasemia syndrome<\/h3>\n\n\n\n<p><a href=\"https:\/\/allergyasthmanetwork.org\/mast-cell-diseases\/hat\/\">Hereditary alpha-tryptasemia (H\u03b1T)<\/a> is a genetic trait. It affects 4-8% of the general population. People with this trait have high levels of the protein alpha tryptase. This protein is found around blood vessels and in mast cells. The tryptase levels become more elevated during an allergic reaction.<\/p>\n\n\n\n<p>Having the trait does not mean you will have mast cell disease symptoms. About one-third of people with HaT don\u2019t have mast cell disease symptoms. Those who do, however, are at higher risk for having systemic mastocytosis and anaphylaxis.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col,.kadence-column19376052_4976e7-95 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{background-color:#f8f7f3;}.kadence-column19376052_4976e7-95 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_4976e7-95{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_4976e7-95 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_4976e7-95\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_4e4096-f8{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_4e4096-f8{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col,.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_4e4096-f8{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_4e4096-f8{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_4e4096-f8{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_4e4096-f8 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_4e4096-f8\"><div class=\"kt-inside-inner-col\"><style>.kb-image19376052_4f640e-7d .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_4f640e-7d size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/doctor-consulting-with-woman-1080x567.jpg\" alt=\"doctor consulting woman in her office\" class=\"kb-img wp-image-1259\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/doctor-consulting-with-woman-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/doctor-consulting-with-woman-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/doctor-consulting-with-woman-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/09\/doctor-consulting-with-woman.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Living with Mast Cell Disease<\/h2>\n\n\n\n<p>Living with a mast cell disease can be hard. Avoiding triggers is a challenge because there are so many. They can range from sudden changes in temperatures to certain foods. Also, symptoms can vary from person to person. They can affect multiple organ systems, including the skin, heart, lungs, gut and bones. When symptoms are severe, it can lead to life-threatening anaphylaxis.<\/p>\n\n\n\n<p>Medications are usually a key part of living with mast cell diseases. These can block the reactivity of mast cells. Managing the condition successfully is also key. You may have to adjust your diet if foods are a trigger. You may have to wear extra layers to protect yourself from sudden changes in weather.<\/p>\n\n\n\n<p>Once you find a doctor knowledgeable in mast cell diseases, discuss your triggers and ways to manage your condition. With planning and preparation, you can live an active life with a mast cell disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mental Health and Mast Cell Disease<\/h2>\n\n\n\n<p>The link between mental health and mast cell diseases is a combination of factors. Mast cell diseases can cause neurologic or psychiatric disorders. The stress of living with a chronic illness that make take years to properly diagnose is a risk factor for mental health problems. Treatment side effects may also contribute to mental health concerns.<\/p>\n\n\n\n<p>Ask your doctor for a referral to a mental health specialist if you don\u2019t already have one. providers.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_faca62-13 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_faca62-13 > .kt-inside-inner-col,.kadence-column19376052_faca62-13 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_faca62-13 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_faca62-13 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_faca62-13 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_faca62-13 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_faca62-13{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_faca62-13 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_faca62-13 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_faca62-13\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_95c4bd-f1{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_95c4bd-f1{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col,.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_95c4bd-f1{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_95c4bd-f1{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_95c4bd-f1{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_95c4bd-f1 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_95c4bd-f1\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading\">Questions &amp; Answers (Q&amp;A) on Mast Cell Diseases<\/h2>\n\n\n\n<p>You may have specific questions about mast cell diseases. Here\u2019s a Q&amp;A with some common questions. If there\u2019s something you\u2019d like to see covered, please&nbsp;<a href=\"mailto:editor@allergyasthmanetwork.org\"><strong>email the editor<\/strong><\/a>&nbsp;with more questions.<\/p>\n\n\n<style>.kt-accordion-id19376052_118479-7f .kt-accordion-inner-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:20px;}.kt-accordion-id19376052_118479-7f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:1px solid #eeeeee;border-bottom:1px solid #eeeeee;border-left:1px solid #eeeeee;border-bottom-right-radius:20px;background:var(--global-palette9, #ffffff);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-sm, 1.5rem);}.kt-accordion-id19376052_118479-7f .wp-block-kadence-pane .kt-accordion-header-wrap .kt-blocks-accordion-header{border-top:1px solid #d8d6d6;border-right:1px solid #d8d6d6;border-bottom:1px solid #d8d6d6;border-left:1px 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.kt-accodion-icon-style-basic ):not( .kt-accodion-icon-style-xclose ):not( .kt-accodion-icon-style-arrow ) .kt-blocks-accordion-header.kt-accordion-panel-active .kt-blocks-accordion-icon-trigger:before{background:var(--global-palette9, #ffffff);}@media all and (max-width: 1024px){.kt-accordion-id19376052_118479-7f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:1px solid #eeeeee;border-bottom:1px solid #eeeeee;border-left:1px solid #eeeeee;}}@media all and (max-width: 1024px){.kt-accordion-id19376052_118479-7f .wp-block-kadence-pane .kt-accordion-header-wrap .kt-blocks-accordion-header{border-top:1px solid #d8d6d6;border-right:1px solid #d8d6d6;border-bottom:1px solid #d8d6d6;border-left:1px solid #d8d6d6;}}@media all and (max-width: 1024px){.kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:hover, body:not(.hide-focus-outline) .kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible{border-top-color:#d4d4d4;border-top-style:solid;border-right-color:#d4d4d4;border-right-style:solid;border-bottom-color:#d4d4d4;border-bottom-style:solid;border-left-color:#d4d4d4;border-left-style:solid;}}@media all and (max-width: 1024px){.kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible, .kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header.kt-accordion-panel-active{border-top-color:#eeeeee;border-top-style:solid;border-right-color:#eeeeee;border-right-style:solid;border-bottom:0px solid #eeeeee;border-left-color:#eeeeee;border-left-style:solid;}}@media all and (max-width: 767px){.kt-accordion-id19376052_118479-7f .kt-accordion-inner-wrap{display:block;}.kt-accordion-id19376052_118479-7f .kt-accordion-inner-wrap .kt-accordion-pane:not(:first-child){margin-top:20px;}.kt-accordion-id19376052_118479-7f .kt-accordion-panel-inner{border-top:0px solid transparent;border-right:1px solid #eeeeee;border-bottom:1px solid #eeeeee;border-left:1px solid #eeeeee;}.kt-accordion-id19376052_118479-7f .wp-block-kadence-pane .kt-accordion-header-wrap .kt-blocks-accordion-header{border-top:1px solid #d8d6d6;border-right:1px solid #d8d6d6;border-bottom:1px solid #d8d6d6;border-left:1px solid #d8d6d6;}.kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:hover, body:not(.hide-focus-outline) .kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible{border-top-color:#d4d4d4;border-top-style:solid;border-right-color:#d4d4d4;border-right-style:solid;border-bottom-color:#d4d4d4;border-bottom-style:solid;border-left-color:#d4d4d4;border-left-style:solid;}.kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header:focus-visible, .kt-accordion-id19376052_118479-7f .kt-accordion-header-wrap .kt-blocks-accordion-header.kt-accordion-panel-active{border-top-color:#eeeeee;border-top-style:solid;border-right-color:#eeeeee;border-right-style:solid;border-bottom:0px solid #eeeeee;border-left-color:#eeeeee;border-left-style:solid;}}<\/style>\n<div class=\"wp-block-kadence-accordion alignnone\"><div class=\"kt-accordion-wrap kt-accordion-id19376052_118479-7f kt-accordion-has-12-panes kt-active-pane-0 kt-accordion-block kt-pane-header-alignment-left kt-accodion-icon-style-basiccircle kt-accodion-icon-side-right\" style=\"max-width:none\"><div class=\"kt-accordion-inner-wrap\" data-allow-multiple-open=\"false\" data-start-open=\"none\">\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-1 kt-pane19376052_d2d0ba-8e\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">What causes mast cell disease?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Researchers aren\u2019t sure what causes mast cell diseases. Studies suggest it is related to genetics. It is believed that a genetic KIT mutation can cause abnormal, overly active or too many mast cells in the body. But it could also be caused by an immunologic condition or hypersensitivity.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-5 kt-pane19376052_d3f37c-a6\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is mast cell disease fatal?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Most mast cell diseases are not fatal. But there are certain rare forms of mast cell disease which can be fatal. These include advanced systemic mastocytosis, such as mast cell leukemia.<\/p>\n\n\n\n<p>Some children and adults with clonal and non-clonal mast cell disease are at risk for an anaphylactic reaction, which can be severe. Anaphylaxis can be fatal if untreated. People diagnosed with mast cell disease should have a written Anaphylaxis Action Plan, carry epinephrine at all times so they have immediate access to treatment, and wear an emergency bracelet.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-6 kt-pane19376052_48055a-0c\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is mast cell disease cancer?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Mast cell diseases are not a type of cancer. Systemic mastocytosis can become cancerous, but most people with systemic mastocytosis have a non-advanced form that does not reduce lifespan.<\/p>\n\n\n\n<p>Some people with non-advanced forms of systemic mastocytosis are at risk for developing advanced forms of the condition, such as mast cell leukemia. If untreated, this can be fatal.<\/p>\n\n\n\n<p>Both non-advanced and advanced forms of systemic mastocytosis are very rare.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-7 kt-pane19376052_25dbad-89\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Can mast cell disease be cured?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>There is no cure for mast cell diseases. People with a mast cell disease can manage symptoms by avoiding triggers and taking medication as prescribed.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-8 kt-pane19376052_1b4f3d-fa\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is chronic urticaria a mast cell disorder?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Chronic urticaria (also called chronic hives) is in part driven my mast cell activation, so it is a type of mast cell disorder. It can be the result of a clonal mast cell disease, such as cutaneous mastocytosis or systemic mastocytosis. It can also result from non-clonal secondary mast cell activation disorders, such as allergen-driven mast cell activation or autoimmune urticaria.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-9 kt-pane19376052_d362a1-44\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is mast cell sarcoma a mast cell disease?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Yes, mast cell sarcoma is a type of mastocytosis. It is a tumor of cancerous mast cells.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-10 kt-pane19376052_976852-9e\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is mast cell disease hereditary?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>Mastocytosis and mast cell activation syndrome appear to involve genetic factors. But they are not strictly hereditary. Just because one person in a family has a mast cell disease does not mean everyone is at risk.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-11 kt-pane19376052_8e74f9-e2\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">Is mast cell disease contagious?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>No, mast cell diseases are not contagious. They are not caused by germs like bacteria or viruses. They cannot be spread from person to person.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-kadence-pane kt-accordion-pane kt-accordion-pane-12 kt-pane19376052_0e9883-c7\"><h3 class=\"kt-accordion-header-wrap\"><button class=\"kt-blocks-accordion-header kt-acccordion-button-label-show\" type=\"button\"><span class=\"kt-blocks-accordion-title-wrap\"><span class=\"kt-blocks-accordion-title\">What does mast cell disease look like?<\/span><\/span><span class=\"kt-blocks-accordion-icon-trigger\"><\/span><\/button><\/h3><div class=\"kt-accordion-panel kt-accordion-panel-hidden\"><div class=\"kt-accordion-panel-inner\">\n<p>People living with mast cell diseases may develop chronic skin rashes. They may feel stomach distress, such as bloating, diarrhea or nausea, usually after eating. They may have breathing problems including nasal congestion, coughing, wheezing and shortness of breath. They may experience sudden abnormal heart rhythm or blood pressure changes, with hypertension or hypotension.<\/p>\n\n\n\n<p>If symptoms become severe enough, it can lead to a life-threatening anaphylactic reaction.<\/p>\n\n\n\n<p>Since mast cell diseases look different for everyone, diagnosis can be tricky. It\u2019s best to discuss your symptoms with a doctor. Ask for mast cell disease testing.<\/p>\n\n\n\n<p>A proactive approach to managing your disease can help. You can work with a registered dietitian to develop a diet that eliminates harmful foods based on your experience with symptoms. You may want to take vitamins and nutrients along with prescribed medications. A comprehensive treatment plan can reduce your symptoms and improve your quality of life.<\/p>\n\n\n\n<p>Find others in the mast cell disease community for support as you go through living with this condition.<\/p>\n<\/div><\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col,.kadence-column19376052_9f4103-4d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{background-color:#f8f7f3;}.kadence-column19376052_9f4103-4d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_9f4103-4d{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_9f4103-4d > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_9f4103-4d\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_df6bfa-49{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_df6bfa-49{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col,.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_df6bfa-49{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_df6bfa-49{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_df6bfa-49{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_df6bfa-49 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_df6bfa-49\"><div class=\"kt-inside-inner-col\"><style>.kb-image19376052_c90050-64 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image19376052_c90050-64 size-large\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/doctor-holding-patient-hands-1080x567.jpg\" alt=\"Two people are sitting at a table. One person&#039;s hands, dressed in a white coat, are gently resting on another&#039;s hands, offering reassurance. A clipboard with a form detailing health insurance options, alongside a pen and laptop, is visible on the table.\" class=\"kb-img wp-image-572\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/doctor-holding-patient-hands-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/doctor-holding-patient-hands-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/doctor-holding-patient-hands-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/doctor-holding-patient-hands.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Patient Story: Mastocytosis and Anaphylaxis<\/h2>\n\n\n\n<p><em>Gail Barbera is a past Board of Directors member of&nbsp;<\/em><a rel=\"noreferrer noopener nofollow\" href=\"https:\/\/tmsforacure.org\/\" target=\"_blank\"><strong><em>The Mast Cell Disease Society<\/em><\/strong><\/a><em>.<\/em><\/p>\n\n\n\n<p>My husband and I had just arrived at a restaurant for dinner with his family. When we were seated, I suddenly began to feel a familiar pain in my stomach. It was like a rock poking my mid-torso. I felt flushed. I knew then I had less than a minute before anaphylaxis struck.<\/p>\n\n\n\n<p>My head began to buzz and my vision \u201cgrayed.\u201d I managed to get my epinephrine and put it in front of my sister-in-law, who is a nurse. Then \u2026 down I went, unconscious on the floor.<\/p>\n\n\n\n<p>I have systemic mastocytosis. It is mast cell disease that involves abnormal mast cells building up in my organs. Due to this, I have experienced anaphylaxis more than a dozen times. It has happened at work, in a store, on the side of the road.<\/p>\n\n\n\n<p>My sister-in-law injected the epinephrine. She called out my name, but I was not able to respond. I felt disoriented, confused, and sleepy. I eventually opened my eyes and heard someone say the ambulance was coming. My husband asked if we could be sent to the hospital where my mastocytosis specialist would be able to provide treatment.<\/p>\n\n\n\n<p>When the ambulance arrived, the EMT put an oxygen mask on me, but I still struggled to get air. The stomach pain was terrible by that point. I had a prescription protocol signed by my doctor just for this type of situation. But the EMTs said they couldn\u2019t give me pain medicine until I had seen a doctor.<\/p>\n\n\n\n<p>At the hospital, the ER staff contacted my mastocytosis specialist. The doctors started an IV, adding antihistamines and morphine. Slowly the pain subsided.<\/p>\n\n\n\n<p>Since the episode, my doctor adjusted my treatment plan to help slow the progression of mastocytosis-related anaphylaxis should it occur again. And I always carry my epinephrine and the prescription protocol with me wherever I go.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col,.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{background-color:var(--global-palette1, #3182CE);}.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_4cf45b-d7{position:relative;}.kadence-column19376052_4cf45b-d7, .kt-inside-inner-col > .kadence-column19376052_4cf45b-d7:not(.specificity){margin-right:0px;margin-left:0px;}@media all and (max-width: 1024px){.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_4cf45b-d7 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_4cf45b-d7\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_fd4ba7-84{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_fd4ba7-84{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col{padding-right:var(--global-kb-spacing-lg, 3rem);padding-left:var(--global-kb-spacing-lg, 3rem);}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col,.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_fd4ba7-84{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_fd4ba7-84{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_fd4ba7-84{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_fd4ba7-84 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_fd4ba7-84\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center has-text-color has-link-color wp-elements-23d58c2c0c25c06f5c26f4d721c68292\" style=\"color:#ffffff;margin-top:0;font-size:24px\">For support and further information about mast cell diseases, please visit <strong><a href=\"https:\/\/tmsforacure.org\/\" rel=\"nofollow noopener\" target=\"_blank\">The Mast Cell Disease Society<\/a><\/strong>.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col,.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{background-color:var(--global-palette9, #ffffff);}.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_e20ebd-10{position:relative;}.kadence-column19376052_e20ebd-10, .kt-inside-inner-col > .kadence-column19376052_e20ebd-10:not(.specificity){margin-right:0px;margin-left:0px;}@media all and (max-width: 1024px){.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_e20ebd-10 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_e20ebd-10\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-sm, 1rem);max-width:1080px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id19376052_2b41f0-a532 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id19376052_2b41f0-a532 alignnone wp-block-kadence-rowlayout\" id=\"mcd-podcasts\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col,.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_d2a3e1-e79{position:relative;}@media all and (max-width: 1024px){.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_d2a3e1-e79 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_d2a3e1-e79\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\" style=\"margin-top:0;font-size:24px\">Mast Cell Disease Podcasts<\/p>\n\n\n<style>.kt-post-loop19376052_2c3b36-3925 .kadence-post-image{padding-top:5px;padding-right:20px;padding-bottom:5px;padding-left:5px;}.kt-post-loop19376052_2c3b36-3925 .kt-feat-image-align-left{grid-template-columns:40% auto;height:100%;}.kt-post-loop19376052_2c3b36-3925 .kadence-post-image .kt-image-ratio-full-height{height:100%;padding-bottom:0px;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item-inner-wrap .kt-blocks-post-grid-item-inner{display:flex;flex-direction:column;justify-content:flex-start;}.kt-post-loop19376052_2c3b36-3925 .kt-post-grid-wrap{gap:30px 30px;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;border-top-color:currentColor;border-top-style:solid;border-right-color:currentColor;border-right-style:solid;border-bottom-color:currentColor;border-bottom-style:solid;border-left-color:currentColor;border-left-style:solid;background-color:#ffffff;overflow:hidden;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item .kt-blocks-post-grid-item-inner{padding-top:10px;padding-right:5px;padding-bottom:10px;padding-left:0px;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item header{padding-top:0px;padding-right:0px;padding-bottom:5px;padding-left:0px;margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item .kt-blocks-above-categories{font-size:13px;line-height:20px;text-transform:uppercase;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item .entry-title{padding-top:5px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;font-size:20px;line-height:1.297em;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item .kt-blocks-post-top-meta{color:#727272;font-size:12px;line-height:1.5em;}.kt-post-loop19376052_2c3b36-3925 .entry-content{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;font-size:14px;line-height:1.5em;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-footer{border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px;font-size:12px;line-height:20px;text-transform:uppercase;}.kt-post-loop19376052_2c3b36-3925 .entry-content:after{height:0px;}.kt-post-loop19376052_2c3b36-3925 .kb-filter-item{border-top-width:0px;border-right-width:0px;border-bottom-width:2px;border-left-width:0px;padding-top:5px;padding-right:8px;padding-bottom:5px;padding-left:8px;margin-top:0px;margin-right:10px;margin-bottom:0px;margin-left:0px;}@media all and (max-width: 1024px){.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item{border-top-color:currentColor;border-top-style:solid;border-right-color:currentColor;border-right-style:solid;border-bottom-color:currentColor;border-bottom-style:solid;border-left-color:currentColor;border-left-style:solid;}}@media all and (max-width: 767px){.kt-post-loop19376052_2c3b36-3925 .kadence-post-image .kt-image-ratio-full-height{height:0px;padding-bottom:133.33%;}.kt-post-loop19376052_2c3b36-3925 .kt-blocks-post-grid-item{border-top-color:currentColor;border-top-style:solid;border-right-color:currentColor;border-right-style:solid;border-bottom-color:currentColor;border-bottom-style:solid;border-left-color:currentColor;border-left-style:solid;}}<\/style><div class=\"wp-block-kadence-postgrid kt-blocks-post-loop-block alignnone kt-post-loop19376052_2c3b36-3925 kt-post-grid-layout-grid \"><div class=\"kt-post-grid-layout-grid-wrap kt-post-grid-wrap\" data-columns-xxl=\"2\" data-columns-xl=\"2\" data-columns-md=\"2\" data-columns-sm=\"2\" data-columns-xs=\"1\" data-columns-ss=\"1\"data-item-selector=\".kt-post-masonry-item\" aria-label=\"Post Carousel\"><article class=\"kt-blocks-post-grid-item post-19384637 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/advanced-systemic-mastocytosis\/\" aria-label=\"Read More What to Know About Advanced Systemic Mastocytosis\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"608\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-Podcast-8-Graphic-1080x608.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a human silhouette, symbolizing Mast Cell Disease, filled with colorful dots and outlined by wavy, radiating lines. The background features a gradient of light blue with scattered dots around the circle, contributing to an abstract, energetic effect.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-Podcast-8-Graphic-1080x608.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-Podcast-8-Graphic-300x169.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-Podcast-8-Graphic-768x432.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-Podcast-8-Graphic.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/advanced-systemic-mastocytosis\/\">What to Know About Advanced Systemic Mastocytosis<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 2 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">In a new podcast, explore the progression of systemic mastocytosis and the various treatment options available.<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384636 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mastocytosis-hematologist-treatments\/\" aria-label=\"Read More Mast Cell Disease, the Hematologist and New Treatments on the Horizon\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-future-treatments-1080x567.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a microscope, test tubes, and a petri dish with colorful samples, overlaid on a silhouette of a human figure. The image is set within a pink-bordered circle against a gradient blue background, symbolizing scientific research.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-future-treatments-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-future-treatments-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-future-treatments-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-future-treatments.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mastocytosis-hematologist-treatments\/\">Mast Cell Disease, the Hematologist and New Treatments on the Horizon<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 2 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">Learn about  the latest mastocytosis treatment \u2013 KIT inhibitors \u2013 with our podcast episode, &#8216;Mast Cell Disease, the Hematologist&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384635 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/living-with-systemic-mastocytosis\/\" aria-label=\"Read More Living with Systemic Mastocytosis\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast6-Living-with-MCD-1080x567.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of silhouettes arranged in a circle, with one silhouette in the center. The central figure is colorful with various dots, while the others are plain blue. The background features concentric circles.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast6-Living-with-MCD-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast6-Living-with-MCD-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast6-Living-with-MCD-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast6-Living-with-MCD.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/living-with-systemic-mastocytosis\/\">Living with Systemic Mastocytosis<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 2 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">Our latest podcast gets the patient perspective on diagnosing and managing systemic mastocytosis, one of the more common mast cell&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384634 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-stress-histamine-diets\/\" aria-label=\"Read More How Do Stress and Low Histamine Diets Impact Mast Cell Disease?\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast5-Stress-1080x567.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a person with colorful dots, holding their head in distress. The background features question marks, exclamation marks, gears, and lightning bolts, symbolizing confusion or anxiety.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast5-Stress-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast5-Stress-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast5-Stress-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-Podcast5-Stress.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-stress-histamine-diets\/\">How Do Stress and Low Histamine Diets Impact Mast Cell Disease?<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 2 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">Our latest podcast examines two hot topics in mast cell diseases: how low histamine diets and stress can affect mast&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384633 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology podcast-category-mast-cell-disease\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-treatment\/\" aria-label=\"Read More How are Mast Cell Diseases Treated?\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"567\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-treatment-1080x567.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a human silhouette with colorful dots, surrounded by medical items like pills, a bottle labeled &quot;Rx&quot;, a syringe, and a medical vial. The background has concentric circles, suggesting a focus on medicine or health.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-treatment-1080x567.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-treatment-300x158.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-treatment-768x403.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/MCD-treatment.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-treatment\/\">How are Mast Cell Diseases Treated?<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 18 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">Our podcast hosts focus on mast cell disease treatment and the multidisciplinary approach that can be helpful in managing these&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384632 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-diagnosis\/\" aria-label=\"Read More How to Diagnose Mast Cell Disease\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"608\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-episode3-podcast-1080x608.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a test tube filled with a colorful, layered liquid, with pink, yellow, and purple hues. The tube is surrounded by concentric circles on a light blue gradient background.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-episode3-podcast-1080x608.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-episode3-podcast-300x169.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-episode3-podcast-768x432.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/MCD-episode3-podcast.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-diagnosis\/\">How to Diagnose Mast Cell Disease<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 19 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">Our podcast co-hosts Kortney Kwong Hing and Payel Gupta, MD, welcome allergist Joshua Milner, MD, to discuss the complexities of&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384630 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/podcast-mast-cell-disease-symptoms-triggers\/\" aria-label=\"Read More \u2018Symptoms and Triggers of Mast Cell Disease\u2019 Podcast\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"1080\" height=\"608\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/AAII-1920x1080_065-website-1080x608.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Abstract illustration of a human silhouette filled with colorful dots, symbolizing the complexity of mast cell disease, surrounded by a pink circle and concentric blue rings on a gradient blue background. The colors transition from pink to yellow from head to feet.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/AAII-1920x1080_065-website-1080x608.jpg 1080w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/AAII-1920x1080_065-website-300x169.jpg 300w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/AAII-1920x1080_065-website-768x432.jpg 768w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/08\/AAII-1920x1080_065-website.jpg 1200w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/podcast-mast-cell-disease-symptoms-triggers\/\">\u2018Symptoms and Triggers of Mast Cell Disease\u2019 Podcast<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 14 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">In this new podcast, Kortney Kwong Hing and Dr. Payel Gupta are joined by Anne Maitland, MD, to discuss symptoms&#8230;<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><article class=\"kt-blocks-post-grid-item post-19384628 podcast type-podcast status-publish has-post-thumbnail hentry podcast-category-immunology\"><div class=\"kt-blocks-post-grid-item-inner-wrap kt-feat-image-align-left kt-feat-image-mobile-align-top\"><div class=\"kadence-post-image\"><div class=\"kadence-post-image-intrisic kt-image-ratio-133-33 kt-image-ratio-full-height\" style=\"\"><div class=\"kadence-post-image-inner-intrisic\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-basic-science\/\" aria-label=\"Read More \u2018Mast Cell Diseases &#038; Systemic Mastocytosis: The Basic Science\u2019\" class=\"kadence-post-image-inner-wrap\"><img decoding=\"async\" width=\"400\" height=\"250\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/01\/Mast-cell-disease-podcast-graphic-1-400x250-1.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"Illustration of a stylized cell cross-section with a blue nucleus and multicolored particles. The cell is surrounded by a circular membrane, and the background features gradient shades of blue.\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/01\/Mast-cell-disease-podcast-graphic-1-400x250-1.jpg 400w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/01\/Mast-cell-disease-podcast-graphic-1-400x250-1-300x188.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" title=\"\"><\/a><\/div><\/div><\/div><div class=\"kt-blocks-post-grid-item-inner\"><header><h3 class=\"entry-title\"><a href=\"https:\/\/allergyasthmanetwork.org\/podcast\/mast-cell-disease-basic-science\/\">\u2018Mast Cell Diseases &#038; Systemic Mastocytosis: The Basic Science\u2019<\/a><\/h3><div class=\"kt-blocks-post-top-meta\"><span class=\"kt-reading-time-wrap\"><span class=\"kt-reading-time\"> <span class=\"kt-reading-time-label\">Reading Time:<\/span> 16 <span class=\"kt-reading-time-postfix\">minutes<\/span> <\/span><\/span><\/div><\/header><div class=\"entry-content\">In this new podcast, Kortney Kwong Hing and Dr. Payel Gupta explore the science behind what causes mast cell diseases.<\/div><footer class=\"kt-blocks-post-footer\"><div class=\"kt-blocks-post-footer-left\"><\/div><div class=\"kt-blocks-post-footer-right\"><\/div><\/footer><\/div><\/div><\/article><\/div><\/div><!-- .wp-block-kadence-postgrid --><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n\n<style>.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col{padding-top:20px;padding-bottom:20px;}.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col,.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_e6d9d8-ee{position:relative;}.kadence-column19376052_e6d9d8-ee, .kt-inside-inner-col > .kadence-column19376052_e6d9d8-ee:not(.specificity){margin-right:20px;margin-left:20px;}@media all and (max-width: 1024px){.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column19376052_e6d9d8-ee > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_e6d9d8-ee\"><div class=\"kt-inside-inner-col\"><style>.kadence-column19376052_c4d9a7-7f{max-width:800px;margin-left:auto;margin-right:auto;}.wp-block-kadence-column.kb-section-dir-horizontal:not(.kb-section-md-dir-vertical)>.kt-inside-inner-col>.kadence-column19376052_c4d9a7-7f{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col,.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col{flex-direction:column;}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column19376052_c4d9a7-7f{position:relative;}@media all and (min-width: 1025px){.wp-block-kadence-column.kb-section-dir-horizontal>.kt-inside-inner-col>.kadence-column19376052_c4d9a7-7f{-webkit-flex:0 1 800px;flex:0 1 800px;max-width:unset;margin-left:unset;margin-right:unset;}}@media all and (max-width: 1024px){.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.wp-block-kadence-column.kb-section-sm-dir-vertical:not(.kb-section-sm-dir-horizontal):not(.kb-section-sm-dir-specificity)>.kt-inside-inner-col>.kadence-column19376052_c4d9a7-7f{max-width:800px;-webkit-flex:1;flex:1;margin-left:auto;margin-right:auto;}.kadence-column19376052_c4d9a7-7f > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column19376052_c4d9a7-7f\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-spacer.kt-block-spacer-19376052_0d0802-90 .kt-block-spacer{height:30px;}.wp-block-kadence-spacer.kt-block-spacer-19376052_0d0802-90 .kt-divider{border-top-width:1px;height:1px;border-top-color:var(--global-palette3, #1A202C);width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-19376052_0d0802-90\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p style=\"margin-top:0\"><em>Reviewed by:<\/em><br><strong>Anne Maitland, MD, FACAAI,<\/strong> is director of Allergy &amp; Immunology Services at the Metrodora Institute. She previously served as assistant professor in the Department of Medicine, Allergy &amp; Clinical Immunology, at Icahn School of Medicine at Mount Sinai in New York City. Dr. Maitland is very active in increasing awareness of immune-mediated disorders. She is also involved with research to continually improve the treatment of allergies, asthma and recurrent infections.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"has-text-align-center\" style=\"margin-bottom:0px\"><em>Supported by:&nbsp;<\/em><\/p>\n\n\n<style>.kb-image19376052_7ec397-5e.kb-image-is-ratio-size, .kb-image19376052_7ec397-5e .kb-image-is-ratio-size{max-width:300px;width:100%;}.wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_7ec397-5e.kb-image-is-ratio-size, .wp-block-kadence-column > .kt-inside-inner-col > .kb-image19376052_7ec397-5e .kb-image-is-ratio-size{align-self:unset;}.kb-image19376052_7ec397-5e figure{max-width:300px;}.kb-image19376052_7ec397-5e .image-is-svg, .kb-image19376052_7ec397-5e .image-is-svg img{width:100%;}.kb-image19376052_7ec397-5e .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image19376052_7ec397-5e\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"600\" height=\"352\" src=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Blueprint-logo-1.jpg\" alt=\"Logo of Blueprint Medicine featuring the company name in a bold, modern font. A stylized DNA strand forms part of the letter &quot;b,&quot; incorporating shades of blue.\" class=\"kb-img wp-image-19381076\" title=\"\" srcset=\"https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Blueprint-logo-1.jpg 600w, https:\/\/allergyasthmanetwork.org\/wp-content\/uploads\/2024\/10\/Blueprint-logo-1-300x176.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mast cells play an important role in our health. These tissue-based immune cells live in every organ in our body. Mast cells act as sentinels for the immune system. They are armed to recognize and respond to foreign invaders, such as a virus or an allergen. 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